US scientists have found the first direct evidence that coronavirus could infect the human brain and replicate inside its cells, heightening concern about the disease’s poorly understood neurological symptoms.
Thomas Hartung and colleagues at Johns Hopkins University made the discovery after adding low levels of Sars-Cov-2, the virus responsible for Covid-19, to tiny neuronal balls known as mini-brains that are grown from human stem cells.
The researchers found the virus infected neurons in the mini-brains via the ACE2 human protein that is known to be an important entry point for Sars-Cov-2. The virus then multiplied within the neurons; within three days the number of copies had increased at least tenfold.
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