观点健康

Why the ‘thrifty gene’ hypothesis is back

An unexpected finding shows that obesity and heart disease do not always go hand-in-hand

The writer is a science commentator

The two-faced Roman god Janus was able to look in opposing directions at once. His likeness often featured on doorways, including Rome’s most famous portal, the Janus Geminus, which remained open while the city-state was at war and closed during peacetime. 

That duality came to mind with the publication last week of a study showing that a genetic mutation that causes obesity might paradoxically also protect against high cholesterol and heart disease. This counter-intuitive link potentially opens the door to future drugs that could target both. 

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