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The race to launch a pill for weight loss

Despite success with injectable drugs pharma companies are investing heavily in tablets, long considered the holy grail of obesity medicine

During the first world war, women working in munitions factories began to dramatically lose weight. These so-called Canary Girls were handling a yellow toxic chemical known as DNP, which sped up their metabolisms and enabled their bodies to burn fats faster.

Soon, drug companies were selling DNP, which is short for 2,4-Dinitrophenol, in pill form. Such was the demand for a weight-loss drug that sales flourished even though in high doses the pills caused cataracts, skin lesions and even death. 

From extracts of animal thyroids in the late 19th century to the fen-phen appetite suppressants of the 1990s, people’s insatiable desire to slim down has led them to experiment with a multitude of inadvisable drugs. 

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