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Moderna breakthrough brings back memories of pandemic mania

Biotech nearly triples as mRNA cancer treatment shows promise after company had struggled in recent years

Moderna made its name in infectious diseases and, ever since the pandemic, it has been desperate to find a new area of speciality. On Wednesday, it did: its mRNA-based melanoma vaccine, jointly developed with Merck, doesn’t just offer a potentially massive market itself, but may also lead to breakthroughs for other cancers, including lung, bladder and kidney.

The Massachusetts-based company will need a number of these to pan out to justify its new, more than doubled, market capitalisation of nearly $60bn.

Moderna needed the break: its revenue had fallen from almost $20bn in 2022, on the success of its Covid-19 vaccine, to $2bn last year. The second Trump administration and its health secretary, Robert F Kennedy Jr, have been less hospitable to vaccines, especially those based on the novel mRNA technology. But cancer treatments are a big market, potentially highly lucrative and less likely to draw political and social controversy.

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